Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21166137 | 0.83 | MAPT (0.34) | MAPTRAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL21165922 | 0.77 | CNR2 (0.35) | MAPTRAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL24813878 | 0.74 | MAPT (0.36) | MAPTRAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL24737152 | 0.74 | NOS1 (0.41) | MAPTRAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL6267324 | 0.73 | NOS1 (0.37) | MAPTRAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL24486530 | 0.73 | — | — | |
| SCHEMBL6904862 | 0.71 | MAPT (0.38) | MAPTRAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL24884220 | 0.71 | NOS1 (0.35) | MAPTRAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL21732638 | 0.71 | RIPK2 (0.35) | MAPTRAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL22306073 | 0.70 | CYP4F2 (0.50) | MAPTSMN1; SMN2HTTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244738-B2 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | ROCHE PALO ALTO LLC (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244738-B2 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | ROCHE PALO ALTO LLC (US) | 2007-07-17 | — | — | US | disclosed |