Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067338 | 0.83 | TRPA1 (0.33) | TRPA1CCR5 | |
| SCHEMBL12409505 | 0.79 | DRD2 (0.32) | — | |
| SCHEMBL14155728 | 0.79 | KDM4E (0.36) | TRPA1CCR5OPRM1OPRD1OPRK1 | |
| SCHEMBL14393894 | 0.76 | KDM4E (0.39) | TRPA1CCR5 | |
| SCHEMBL20803752 | 0.75 | — | — | |
| SCHEMBL23219744 | 0.74 | TRPA1 (0.33) | TRPA1 | |
| SCHEMBL13656277 | 0.73 | KCNH2 (0.39) | TRPA1CCR5OPRM1 | |
| SCHEMBL12376550 | 0.72 | ALDH1A1 (0.34) | TRPA1 | |
| SCHEMBL18390477 | 0.72 | TSHR (0.37) | — | |
| SCHEMBL14979151 | 0.71 | NPSR1 (0.36) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | TRPA1 2435/4885CCR5 1844/4885OPRM1 827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.