Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 5/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20422066 | 0.75 | MAPT (0.52) | KDM4EAPAF1ALDH1A1POLBMAPT | |
| SCHEMBL5262850 | 0.75 | PDE3B (0.43) | POLB | |
| SCHEMBL14463637 | 0.72 | PDE10A (0.41) | ALDH1A1TNKSTNKS2 | |
| SCHEMBL14463639 | 0.71 | TNKS (0.35) | KDM4EALDH1A1MAPTTNKSTNKS2 | |
| SCHEMBL7246305 | 0.70 | ADRA1D (0.43) | KDM4EALDH1A1MAPTHTR3A | |
| SCHEMBL5262020 | 0.67 | LMNA (0.39) | ACVR1TGFBR1KDM4EALDH1A1POLB | |
| SCHEMBL20422067 | 0.67 | PARP1 (0.51) | ITGB3ITGA2BNCF1HTR3ATNKS | |
| SCHEMBL20422063 | 0.67 | GFER (0.55) | KDM4EITGB3ITGA2BNCF1HTR3A | |
| SCHEMBL20422061 | 0.67 | MAPT (0.45) | KDM4EAPAF1ALDH1A1POLBMAPT | |
| SCHEMBL5263885 | 0.66 | DCTPP1 (0.36) | ADRA2AKCNH2KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644343-B1 | 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2007-07-04 | — | — | EP | disclosed |