Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14463835 | 0.96 | NPC1 (0.41) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14463476 | 0.93 | NPC1 (0.39) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14463582 | 0.93 | NPC1 (0.50) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14463415 | 0.90 | RAB9A (0.39) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14463826 | 0.89 | NPC1 (0.39) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL4924591 | 0.89 | NPC1 (0.41) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14463475 | 0.88 | NPC1 (0.39) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14463417 | 0.86 | RAB9A (0.39) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL4921970 | 0.86 | NPC1 (0.40) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14463583 | 0.86 | EPHX2 (0.43) | NPC1RAB9ATP53LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1810677-A1 | RECEPTOR FUNCTION REGULATING AGENT | Takeda Pharmaceutical Company Limited (JP) | 2007-07-25 | — | — | EP | disclosed |