Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841236 | 0.91 | MEN1 (0.53) | LMNAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4297687 | 0.87 | MEN1 (0.47) | SMN1; SMN2HTTMEN1KMT2ANPC1 | |
| SCHEMBL25393509 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAKCNH2HTTCCR1 | |
| SCHEMBL5369952 | 0.81 | LMNA (0.50) | SMN1; SMN2LMNAHTTMEN1KMT2A | |
| SCHEMBL22389656 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAHTTCCR1GAA | |
| SCHEMBL6191239 | 0.79 | MEN1 (0.48) | LMNAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL3331774 | 0.78 | CTSL (0.47) | SMN1; SMN2LMNAKCNH2MEN1KMT2A | |
| SCHEMBL1446859 | 0.77 | MEN1 (0.48) | HTTMEN1KMT2A | |
| SCHEMBL25532258 | 0.77 | LMNA (0.48) | SMN1; SMN2LMNAHTTMEN1KMT2A | |
| SCHEMBL5629529 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297153-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009131940-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |