Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.58 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | ALPG | P10696 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | UBE2M | P61081 | 1/20 | 0.53 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23109077 | 0.91 | MGLL (0.64) | MGLLMALT1KMT2AALPLALPI | |
| SCHEMBL2246607 | 0.86 | MEN1 (0.69) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL2449231 | 0.85 | F10 (0.56) | MGLLKMT2AALPLALPIALPG | |
| SCHEMBL27852313 | 0.83 | MEN1 (0.49) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL1720856 | 0.83 | MGLL (0.56) | MGLLALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL18395563 | 0.83 | KMT2A (0.58) | MGLLKMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL4141969 | 0.82 | HPGD (0.69) | KMT2ASMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL28431130 | 0.82 | GRK2 (0.58) | ALDH1A1SMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL27347877 | 0.82 | F10 (0.63) | MGLLKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL259383 | 0.82 | NPSR1 (0.78) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341396-B | Novel monoacylglycerol esterase inhibitor and preparation method and application thereof | 四川大学华西医院 | 2022-07-26 | — | — | CN | disclosed |
| WO-2021042911-A1 | MAGL INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 鲁南制药集团股份有限公司 | 2021-03-11 | — | — | WO | disclosed |
| CN-112341396-A | Novel monoacylglycerol esterase inhibitor and preparation method and application thereof | 四川大学华西医院 | 2021-02-09 | — | — | CN | disclosed |
| EP-2297153-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |