Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.40 |
| ▸ | MMP3 | P08254 | 4/20 | 0.40 |
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | MMP13 | P45452 | 4/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 9/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP7 | P09237 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30659245 | 0.79 | SMN1; SMN2 (0.56) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL346648 | 0.79 | SMN1; SMN2 (0.56) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL1446592 | 0.78 | USP2 (0.43) | POLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL9405372 | 0.75 | POLB (0.73) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL31386109 | 0.75 | POLB (0.52) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL30135752 | 0.74 | POLB (0.55) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL4725898 | 0.74 | POLB (0.55) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL27842859 | 0.74 | POLB (0.58) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL17144281 | 0.73 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL27826063 | 0.73 | SMN1; SMN2 (0.65) | LMNAPOLBSMN1; SMN2OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297153-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009131940-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |