Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LSS | P48449 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | F13A1 | P00488 | 3/20 | 0.46 |
| ▸ | TGM2 | P21980 | 3/20 | 0.46 |
| ▸ | TGM1 | P22735 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469583 | 0.88 | POLB (0.53) | POLBLSSNPC1ALDH1A1LMNA | |
| SCHEMBL14469477 | 0.84 | KMT2A (0.58) | POLBALDH1A1LMNATSHRKMT2A | |
| SCHEMBL14469556 | 0.82 | ALDH1A1 (0.47) | POLBNPC1ALDH1A1HTTTSHR | |
| SCHEMBL14469569 | 0.82 | ALDH1A1 (0.47) | POLBNPC1ALDH1A1TSHRKMT2A | |
| SCHEMBL14469465 | 0.82 | ALDH1A1 (0.49) | POLBALDH1A1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL14469460 | 0.81 | KMT2A (0.51) | POLBALDH1A1HTTTSHRKMT2A | |
| SCHEMBL14469195 | 0.81 | CHRM1 (0.53) | CNR1 | |
| SCHEMBL14469194 | 0.81 | ALDH1A1 (0.38) | POLBALDH1A1LMNAHTTTSHR | |
| SCHEMBL14469473 | 0.80 | KMT2A (0.43) | POLBALDH1A1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL14469451 | 0.79 | TSHR (0.46) | ALDH1A1LMNATSHRKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |