Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469477 | 0.87 | KMT2A (0.58) | ALDH1A1KDM4EMEN1TSHRKMT2A | |
| SCHEMBL14469558 | 0.86 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTHTTNPSR1 | |
| SCHEMBL14469465 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1TSHRKMT2A | |
| SCHEMBL14469460 | 0.84 | KMT2A (0.51) | ALDH1A1KDM4EMAPTHTTNPSR1 | |
| SCHEMBL14469473 | 0.83 | KMT2A (0.43) | ALDH1A1KDM4EMEN1TSHRKMT2A | |
| SCHEMBL14469569 | 0.83 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1TSHRKMT2A | |
| SCHEMBL14469184 | 0.82 | POLB (0.57) | ALDH1A1HTTTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL14469560 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTHTTMEN1 | |
| SCHEMBL14469451 | 0.82 | TSHR (0.46) | ALDH1A1KDM4EMEN1TSHRKMT2A | |
| SCHEMBL14469456 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1KDM4EMAPTHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |