Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469592 | 0.82 | LSS (0.42) | MEN1HTTKMT2AALDH1A1LMNA | |
| SCHEMBL14469188 | 0.79 | ALDH1A1 (0.46) | MEN1KMT2ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14469583 | 0.77 | POLB (0.53) | HTTKMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL14095182 | 0.76 | CYP3A4 (0.38) | — | |
| SCHEMBL14469235 | 0.76 | CNR1 (0.45) | HTTKMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL14078074 | 0.75 | CYP3A4 (0.36) | MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL14469365 | 0.75 | KDM4E (0.48) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL14456944 | 0.74 | MEN1 (0.59) | MEN1HTTKMT2A | |
| SCHEMBL14469573 | 0.74 | MTNR1B (0.39) | MEN1KMT2AMAPK8ALDH1A1SMN1; SMN2 | |
| SCHEMBL14469586 | 0.74 | CNR1 (0.41) | KMT2AALDH1A1LMNAPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |