Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469568 | 0.93 | S1PR5 (0.52) | KMT2ASMN1; SMN2TP53ALDH1A1L3MBTL1 | |
| SCHEMBL14469452 | 0.90 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2TP53KDM4EL3MBTL1 | |
| SCHEMBL14469456 | 0.88 | SMN1; SMN2 (0.50) | KMT2ASMN1; SMN2TP53KDM4EALDH1A1 | |
| SCHEMBL14469562 | 0.87 | L3MBTL1 (0.47) | KMT2ASMN1; SMN2TP53KDM4EALDH1A1 | |
| SCHEMBL14469477 | 0.86 | KMT2A (0.58) | KMT2ASMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL14469549 | 0.86 | KDM4E (0.50) | KMT2AKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL14469469 | 0.85 | KDM4E (0.49) | KMT2ASMN1; SMN2KDM4EALDH1A1TDP1 | |
| SCHEMBL14469190 | 0.85 | CYP3A4 (0.48) | KMT2AMEN1TSHR | |
| SCHEMBL14469555 | 0.84 | SMN1; SMN2 (0.48) | KMT2ASMN1; SMN2TP53KDM4EALDH1A1 | |
| SCHEMBL14469460 | 0.84 | KMT2A (0.51) | KMT2ASMN1; SMN2TP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |