Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469568 | 0.92 | S1PR5 (0.52) | SMN1; SMN2TP53HRH3KMT2AS1PR5 | |
| SCHEMBL14469449 | 0.90 | KMT2A (0.53) | SMN1; SMN2TP53KMT2AS1PR5L3MBTL1 | |
| SCHEMBL14469463 | 0.90 | KDM4E (0.48) | SMN1; SMN2TP53KMT2ACYP3A4CYP2D6 | |
| SCHEMBL14469456 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53KMT2AMEN1TSHR | |
| SCHEMBL14469562 | 0.86 | L3MBTL1 (0.47) | SMN1; SMN2TP53KMT2AL3MBTL1MEN1 | |
| SCHEMBL14469460 | 0.85 | KMT2A (0.51) | SMN1; SMN2TP53KMT2AMEN1TSHR | |
| SCHEMBL14469477 | 0.85 | KMT2A (0.58) | SMN1; SMN2KMT2AMEN1TSHRKDM4E | |
| SCHEMBL14469466 | 0.84 | MEN1 (0.39) | SMN1; SMN2TP53KMT2AMEN1TSHR | |
| SCHEMBL14469190 | 0.84 | CYP3A4 (0.48) | KMT2ACYP3A4CYP2D6MEN1TSHR | |
| SCHEMBL14469555 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2TP53KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |