Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469553 | 0.90 | KDM4E (0.61) | KDM4EALDH1A1LMNAHTTPOLB | |
| SCHEMBL14469452 | 0.90 | SMN1; SMN2 (0.47) | KDM4EMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL14469462 | 0.85 | FAAH (0.50) | KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL14469476 | 0.85 | FAAH (0.50) | KDM4EALDH1A1LMNAHTTPOLB | |
| SCHEMBL14469464 | 0.85 | MEN1 (0.45) | KDM4EALDH1A1LMNAHTTPOLB | |
| SCHEMBL14469115 | 0.85 | MEN1 (0.49) | KDM4EALDH1A1HTTPOLBMEN1 | |
| SCHEMBL14469179 | 0.85 | ADRB2 (0.54) | KDM4EALDH1A1HTTPOLBMEN1 | |
| SCHEMBL14469472 | 0.84 | FAAH (0.51) | KDM4EALDH1A1LMNAHTTPOLB | |
| SCHEMBL14469477 | 0.84 | KMT2A (0.58) | KDM4EALDH1A1LMNAPOLBMEN1 | |
| SCHEMBL14469470 | 0.83 | FAAH (0.52) | KDM4EALDH1A1LMNAHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |