Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469366 | 0.88 | CNR1 (0.58) | TSHRCNR1ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL14469240 | 0.82 | CNR1 (0.58) | CNR1NPSR1LMNA | |
| SCHEMBL14469235 | 0.82 | CNR1 (0.45) | CNR1ALDH1A1NPSR1HTT | |
| SCHEMBL14469582 | 0.81 | CNR1 (0.47) | TP53CNR1NPSR1HTT | |
| SCHEMBL14469583 | 0.80 | POLB (0.53) | TSHRCNR1ALDH1A1NPSR1HTT | |
| SCHEMBL14469581 | 0.79 | ALDH1A1 (0.45) | TSHRCNR1ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL14469234 | 0.79 | ALDH1A1 (0.38) | MAPTTSHRCNR1ALDH1A1KDM4E | |
| SCHEMBL14469298 | 0.78 | MEN1 (0.47) | TSHRALDH1A1KDM4E | |
| SCHEMBL14469170 | 0.78 | KDM4E (0.48) | MAPTTSHRALDH1A1NPSR1KDM4E | |
| SCHEMBL14469586 | 0.78 | CNR1 (0.41) | TSHRCNR1ALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |