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SCHEMBL144702

SCHEMBL144702

Cc1c(CCC(=O)O)c[nH]c1/C=C1\C(=O)Nc2ccc(S(=O)(=O)Cc3ccccc3)cc21

nearest known ligand 0.76

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PDGFRB P09619 12/20 0.76
▸ FGFR1 P11362 11/20 0.76
▸ KDR P35968 11/20 0.76
▸ ZAP70 P43403 2/20 0.69
▸ AKT2 P31751 1/20 0.63
▸ EGFR P00533 5/20 0.63
▸ AURKA O14965 3/20 0.60
▸ SRC P12931 2/20 0.52
▸ FLT1 P17948 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4407240 0.87 KDR (1.00) PDGFRBFGFR1KDRZAP70AKT2
SCHEMBL4407243 0.87 KDR (1.00) PDGFRBFGFR1KDRZAP70AKT2
SCHEMBL6514860 0.86 AKT2 (0.58) PDGFRBFGFR1KDRZAP70AKT2
SCHEMBL4408840 0.85 PDGFRB (0.80) PDGFRBFGFR1KDRZAP70AKT2
SCHEMBL4408837 0.85 PDGFRB (0.80) PDGFRBFGFR1KDRZAP70AKT2
SCHEMBL147260 0.84 FGFR1 (0.76) PDGFRBFGFR1KDRZAP70AKT2
SCHEMBL141346 0.84 AURKA (0.64) PDGFRBFGFR1KDRZAP70EGFR
SCHEMBL4414657 0.83 PDGFRB (0.80) PDGFRBFGFR1KDRZAP70AKT2
SCHEMBL4414661 0.83 PDGFRB (0.80) PDGFRBFGFR1KDRZAP70AKT2
SCHEMBL4407137 0.82 PDGFRB (0.81) PDGFRBFGFR1KDRZAP70AKT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6599902-B2 For treating or preventing a protein kinase related disorder SUGEN, INC. 2003-07-29 — — US claimed
US-20030125370-A1 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS SUGEN, INC. 2003-07-03 — — US claimed
US-20140221455-A1 DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR Verva Pharmaceuticals, Inc. (AU) 2014-08-07 — — US disclosed
US-20120059047-A1 DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR VERVA PHARMACEUTICALS PTY LTD (AU) 2012-03-08 — — US disclosed
US-20050282733-A1 Differentiation modulating agents and uses therefor VERVA PHARMACEUTICALS PTY LTD (AU) 2005-12-22 — — US disclosed
US-6599902-B2 For treating or preventing a protein kinase related disorder SUGEN, INC. 2003-07-29 — — US disclosed
US-20030125370-A1 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS SUGEN, INC. 2003-07-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120059047-A1 DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR FGF1, FABP4, FGF2 PDGFRB 467/4885FGFR1 5/4885KDR 1077/4885
US-20050282733-A1 Differentiation modulating agents and uses therefor FGF1, FABP4, FGF2 PDGFRB 467/4885FGFR1 5/4885KDR 1077/4885
US-20030125370-A1 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS DMPK, ADK, MAP3K20 PDGFRB 348/4885FGFR1 637/4885KDR 398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.