SCHEMBL14470569

SCHEMBL14470569

CCC1(NC(=O)c2cc(N)cc(C)c2NC(=O)c2cc(OCC(F)(F)F)nn2-c2ncccc2Cl)CS(=O)(=O)C1

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DGAT2 Q96PD7 1/20 0.33
CNR2 P34972 6/20 0.32
CACNA1G O43497 2/20 0.31
CACNA1H O95180 2/20 0.31
CACNA1I Q9P0X4 1/20 0.31
PTGER4 P35408 1/20 0.31
BACE1 P56817 1/20 0.30
BACE2 Q9Y5Z0 1/20 0.30
SCN9A Q15858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10280536 0.93 DGAT2 (0.34) DGAT2CNR2CACNA1GCACNA1HCACNA1I
SCHEMBL14470468 0.92 DGAT2 (0.38) DGAT2CACNA1GCACNA1HCACNA1IBACE1
SCHEMBL10280359 0.91 SLC2A1 (0.33) DGAT2CNR2CACNA1GCACNA1HCACNA1I
SCHEMBL14470469 0.87 MALT1 (0.31) DGAT2
SCHEMBL14470570 0.86 CRHR1 (0.34) DGAT2
SCHEMBL10239615 0.85 DGAT2 (0.38) DGAT2BACE1BACE2
SCHEMBL10280390 0.84 KLKB1 (0.34) DGAT2
SCHEMBL10279970 0.83 DGAT2 (0.37) DGAT2
SCHEMBL14470722 0.81 DGAT2 (0.35) DGAT2
SCHEMBL10280361 0.81 KLKB1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007080131-A2 ANTHRANILAMIDE DERIVATIVES AND THEIR USE FOR THE CONTROL OF INSECTS AND ACARI SYNGENTA PARTICIPATIONS AG (CH) 2007-07-19 WO disclosed