Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5468452 | 0.85 | TLR8 (0.45) | CXCR3TLR8NPC1LMNATP53 | |
| SCHEMBL5482661 | 0.85 | CXCR3 (0.53) | CXCR3TLR8NPC1LMNATP53 | |
| SCHEMBL5463737 | 0.78 | PRMT5 (0.47) | CXCR3TLR8NPC1LMNATP53 | |
| SCHEMBL5453372 | 0.78 | TLR8 (0.41) | CXCR3TLR8NPC1LMNATP53 | |
| SCHEMBL5090938 | 0.75 | CXCR3 (0.47) | CXCR3TLR8CXCR4 | |
| SCHEMBL5468418 | 0.74 | POLB (0.55) | CXCR3TLR8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5480685 | 0.71 | TLR8 (0.48) | CXCR3TLR8LMNACXCR4 | |
| SCHEMBL5473914 | 0.71 | PRMT5 (0.49) | CXCR3TLR8CXCR4 | |
| SCHEMBL14373235 | 0.67 | PRMT5 (0.43) | CXCR3TLR8TP53CXCR4 | |
| SCHEMBL8641718 | 0.65 | HDAC6 (0.59) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084728-A2 | 2-IMINO-BENZIMIDAZOLES | ABBOTT LABORATORIES (US) | 2007-07-26 | — | — | WO | disclosed |