Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536885 | 0.83 | RAB9A (0.57) | ALDH1A1HPGDKDM4EGAANPC1 | |
| SCHEMBL700800 | 0.80 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL27730322 | 0.80 | MCL1 (0.62) | ALDH1A1HPGDKDM4EGAALMNA | |
| SCHEMBL7434216 | 0.77 | KDM4E (0.64) | ALDH1A1HPGDKDM4EGAANPC1 | |
| SCHEMBL16098077 | 0.73 | HPGD (1.00) | ALDH1A1HPGDKDM4ENPC1LMNA | |
| SCHEMBL3483013 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HPGDPOLBSMN1; SMN2CYP1A2 | |
| SCHEMBL13386557 | 0.72 | ALDH1A1 (0.71) | ALDH1A1HPGDKDM4EGAANPC1 | |
| SCHEMBL12984605 | 0.72 | ALDH1A1 (0.63) | ALDH1A1HPGDKDM4EGAAPGR | |
| SCHEMBL10757133 | 0.72 | ALDH1A1 (0.66) | ALDH1A1KDM4EPOLBCYP1A2CNR2 | |
| SCHEMBL153959 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4EGAAPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603912-B1 | SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS CH (CH) | 2007-07-18 | — | — | EP | disclosed |
| EP-1460070-B1 | Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators | SANTHERA PHARMACEUTICALS CH (CH) | 2007-05-16 | — | — | EP | disclosed |