Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11186759 | 0.85 | KDM4E (0.58) | RAB9AKDM4ESMN1; SMN2LMNACRHBP | |
| SCHEMBL14470971 | 0.83 | ALDH1A1 (0.58) | RAB9AKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11617074 | 0.80 | ALDH1A1 (0.47) | RAB9AKDM4ESMN1; SMN2LMNACRHBP | |
| SCHEMBL13742183 | 0.77 | KDM4E (0.70) | KDM4ESMN1; SMN2CRHBPCRHR2ALDH1A1 | |
| SCHEMBL38660347 | 0.75 | KDM4E (0.86) | KDM4ESMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL11615933 | 0.73 | RAB9A (0.43) | RAB9AKDM4ESMN1; SMN2LMNACRHBP | |
| SCHEMBL6752352 | 0.73 | KDM4E (0.71) | KDM4ESMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL8244872 | 0.73 | KDM4E (0.67) | KDM4ESMN1; SMN2CRHBPCRHR2ALDH1A1 | |
| SCHEMBL11621562 | 0.73 | ALDH1A1 (0.48) | RAB9AKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16120076 | 0.73 | CNR2 (0.85) | KDM4ESMN1; SMN2LMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460070-B1 | Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators | SANTHERA PHARMACEUTICALS CH (CH) | 2007-05-16 | — | — | EP | disclosed |