Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14474623 | 0.89 | CHRNB2 (0.50) | CYP11B2ABCG2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL14474599 | 0.80 | CHRNB2 (0.48) | ABCG2CHRNB2CHRNA5CHRNA4GBA1 | |
| SCHEMBL14474620 | 0.80 | PDE5A (0.43) | CYP11B2ABCG2CYP11B1CYP17A1GBA1 | |
| SCHEMBL16186207 | 0.77 | CYP11B2 (0.48) | CYP11B2ABCG2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL19204125 | 0.76 | CYP11B2 (0.47) | CYP11B2ABCG2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL14731287 | 0.74 | CYP11B2 (0.45) | CYP11B2ABCG2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL16184298 | 0.74 | ABCG2 (0.51) | CYP11B2ABCG2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL17214442 | 0.69 | CYP11B2 (0.56) | CYP11B2ABCG2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL14475003 | 0.69 | CYP11B2 (0.56) | CYP11B2ABCG2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL6188982 | 0.69 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP17A1CHRNB2CHRNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013003586-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-03 | — | — | WO | disclosed |