Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.38 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061748 | 0.72 | CHRM2 (0.49) | CHRM2ADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL29858318 | 0.72 | CHRM2 (0.49) | CHRM2ADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL31676061 | 0.70 | KMT2A (0.36) | CHRM2ADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL17865988 | 0.70 | PARP1 (0.40) | HTR2AHTR2CHTR2BALDH1A1TDP1 | |
| SCHEMBL4231166 | 0.69 | CHRM2 (0.47) | CHRM2ADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL14358172 | 0.69 | CHRM2 (0.47) | CHRM2ADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL29734668 | 0.67 | CHRM2 (0.44) | CHRM2ADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL17033019 | 0.66 | ALDH1A1 (0.42) | HTR2AHTR2CHTR2BALDH1A1SIGMAR1 | |
| SCHEMBL17169696 | 0.66 | MMP2 (0.46) | ALDH1A1MAPTTDP1TP53MEN1 | |
| SCHEMBL10427193 | 0.66 | NPSR1 (0.42) | HTR2AHTR2CHTR2BMAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073819-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073819-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2014-08-07 | — | — | US | disclosed |
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2014-08-07 | — | — | US | disclosed |
| WO-2013003669-A2 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | KCNQ5, KCNQ3, KCNQ2 | CHRM2 792/4885ADRA2A 603/4885HTR2A 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.