Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.69 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.69 |
| ▸ | FOLH1 | Q04609 | 8/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397444 | 1.00 | ANPEP (0.69) | ANPEPENPEPFOLH1SLC6A2TAAR1 | |
| SCHEMBL9622159 | 1.00 | ANPEP (0.69) | ANPEPENPEPFOLH1SLC6A2TAAR1 | |
| Hydrochloric Acid SCHEMBL27656347 | 0.98 | ANPEP (0.67) | ANPEPENPEPFOLH1SLC6A2TAAR1 | |
| Isophthalic Acid SCHEMBL28055755 | 0.91 | SLC6A2 (0.66) | ANPEPENPEPFOLH1SLC6A2TAAR1 | |
| Trifluoroacetamide SCHEMBL9181331 | 0.89 | ANPEP (0.57) | ANPEPENPEPFOLH1SLC6A2TAAR1 | |
| SCHEMBL765921 | 0.87 | FOLH1 (0.61) | ANPEPENPEPFOLH1 | |
| Amphetamine SCHEMBL21464672 | 0.87 | TAAR1 (0.70) | ANPEPENPEPSLC6A2TAAR1MAOA | |
| Amphetamine SCHEMBL29185448 | 0.87 | TAAR1 (0.70) | ANPEPENPEPSLC6A2TAAR1MAOA | |
| Glutamic Acid SCHEMBL1033856 | 0.86 | FOLH1 (0.53) | ANPEPENPEPFOLH1SLC7A5 | |
| SCHEMBL1043826 | 0.86 | ANPEP (0.55) | ANPEPENPEPSLC6A2TAAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103724328-B | Cyclic pyrimidin-4-the methane amide of inflammation, asthma and COPD is used for the treatment of as CCR2 receptor antagonist | BOEHRINGER INGELHEIM INT (DE) | 2015-10-14 | — | — | CN | disclosed |
| CN-102256963-B | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD | BOEHRINGER INGELHEIM INT | 2014-06-11 | — | — | CN | disclosed |
| CN-103724328-A | Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd | BOEHRINGER INGELHEIM INT | 2014-04-16 | — | — | CN | disclosed |
| US-8343928-B2 | Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus | SEATTLE GENETICS, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| CN-102256963-A | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD | BOEHRINGER INGELHEIM INT | 2011-11-23 | — | — | CN | disclosed |
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | disclosed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | disclosed |