SCHEMBL144807

SCHEMBL144807

C[Si](Cl)(Cl)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.44
ESR2 Q92731 1/20 0.44
NR1H2 P55055 2/20 0.35
NR1H3 Q13133 2/20 0.35
TSHR P16473 5/20 0.35
LMNA P02545 1/20 0.35
ALOX12 P18054 1/20 0.35
ACHE P22303 1/20 0.35
MAPT P10636 1/20 0.34
ALDH1A1 P00352 2/20 0.33
HSD17B10 Q99714 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31
NOS3 P29474 1/20 0.31
NOS1 P29475 1/20 0.31
MAOA P21397 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9359904 0.92 ESR1 (0.39) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL6519029 0.92 ESR1 (0.39) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL6047833 0.87 ESR1 (0.37) ESR1ESR2NR1H2NR1H3MAPT
SCHEMBL8378715 0.84 CYP1A2 (0.46) ESR1ESR2MAPTALDH1A1HSD17B10
SCHEMBL28979153 0.83 ESR1 (0.34) ESR1ESR2TSHRCA4
SCHEMBL11128894 0.83 ESR1 (0.34) ESR1ESR2MAPTTP53
SCHEMBL11296187 0.83 ESR1 (0.34) ESR1ESR2
SCHEMBL703791 0.83 ALDH1A1 (0.36) ESR1ESR2ALDH1A1
SCHEMBL9383203 0.81 ESR1 (0.44) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL68909 0.81 ESR1 (0.44) ESR1ESR2NR1H2NR1H3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3957 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122060169-A Silicon-hydrogen-terminated silicon-containing aryne resin and preparation method and application thereof 华东理工大学 2026-05-19 CN claimed
US-12617947-B2 Flame-retardant flexible coating composition, flame-retardant product having flame-retardant flexible coating layer and method for manufacturing the same AXEED INC. (KR) 2026-05-05 US claimed
WO-2025233670-A1 HYDROPHOBIC BINDER COMPOSITION AND A PROCESS FOR ITS PREPARATION CHEMTECH SPECIALITY INDIA PVT. LTD. (IN) 2025-11-13 WO claimed
CN-120082231-A Weather-resistant deformation-resistant heavy-duty anticorrosive coating system 深圳市希顺有机硅科技有限公司 2025-06-03 CN claimed
CN-120040771-A Hafnium hybridization carbon-rich polysiloxane flexible ablation material, preparation method and application thereof 四川大学 2025-05-27 CN claimed
CN-119317034-B High-heat-resistance copper-clad plate and preparation process thereof 江西联茂电子科技有限公司 2025-05-13 CN claimed
CN-119899387-A Method for preparing polycarbosilane by using Grignard reagent 汕头大学 2025-04-29 CN claimed
CN-116478404-B Vinyl phenyl silicone resin and injection-moldable ceramic organic silicon fireproof material 浙江葆润应用材料有限公司 2025-04-25 CN claimed
CN-119613736-A Hydroxyl-terminated silicone oil containing fluorine and boron and preparation method thereof 沈阳化工大学 2025-03-14 CN claimed
CN-119570213-A Environment-friendly degradable plastic-wood material and preparation method thereof 美新科技股份有限公司 2025-03-07 CN claimed
EP-0119404-A1 Fluorine-containing polymer and process for its preparation SAGAMI CHEMICAL RESEARCH CENTER (JP) 1984-09-26 EP claimed
US-4464460-A Process for making an imaged oxygen-reactive ion etch barrier INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1984-08-07 US claimed
EP-0103824-A2 Separation of chlorosilanes DOW CORNING CORPORATION (US) 1984-03-28 EP claimed
US-4402796-A WITH SULFOLANE AND HYDROCARBONS COSOLVENTS DOW CORNING CORPORATION (US) 1983-09-06 US claimed
EP-0077794-A1 SOLUBLE POLYSILASTYRENE AND METHOD FOR PREPARATION WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1983-05-04 EP claimed
WO-1982003862-A1 SOLUBLE POLYSILASTYRENE AND METHOD FOR PREPARATION WISCONSIN ALUMNI RES FOUND (US) 1982-11-11 WO claimed
US-4324901-A Soluble polysilastyrene and method for preparation WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1982-04-13 US claimed
US-4260780-A Phenylmethylpolysilane polymers and process for their preparation THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1981-04-07 US claimed
US-4228092-A BY ALCOHOL ESTERIFICATION DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1980-10-14 US claimed
US-4033991-A REACTING HALOGENOSILANE WITH A METAL OXIME SHIN-ETSU CHEMICAL COMPANY, LIMITED (JA) 1977-07-05 US claimed