Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549733 | 1.00 | RET (0.45) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL15665353 | 1.00 | RET (0.45) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL15665354 | 1.00 | RET (0.45) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL9793694 | 0.85 | RET (0.36) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL9793697 | 0.85 | RET (0.36) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL9426196 | 0.78 | RET (0.49) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL30231793 | 0.76 | MAPK14 (0.46) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL1788714 | 0.76 | RET (0.51) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL1786883 | 0.76 | RET (0.51) | RETMAPK14CAMK1DHDAC6TBXA2R | |
| SCHEMBL3708800 | 0.76 | RET (0.51) | RETMAPK14CAMK1DHDAC6TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235696-B2 | can be prepared in an efficient manner and their electronic and steric properties are variable to a wide degree starting from readily available reactants; exhibit good performance in asymmetric syntheses | LANXESS DEUTSCHLAND GMBH (DE) | 2007-06-26 | — | — | US | disclosed |