Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.47 |
| ▸ | USP2 | O75604 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14553602 | 0.88 | PGR (0.54) | USP2SMN1; SMN2PGRALDH1A1LMNA | |
| SCHEMBL14484764 | 0.88 | PGR (0.51) | CYP3A4USP2SMN1; SMN2PGRALDH1A1 | |
| SCHEMBL14553610 | 0.87 | GABRG2 (0.40) | CYP3A4USP2SMN1; SMN2PGRALDH1A1 | |
| SCHEMBL14484821 | 0.85 | PGR (0.62) | CYP3A4USP2SMN1; SMN2PGRALDH1A1 | |
| SCHEMBL14488789 | 0.84 | PGR (0.56) | CYP3A4USP2SMN1; SMN2PGRALDH1A1 | |
| SCHEMBL14553699 | 0.84 | PGR (0.50) | SMN1; SMN2PGRALDH1A1LMNAPKM | |
| SCHEMBL14484319 | 0.84 | PGR (0.56) | CYP3A4USP2SMN1; SMN2PGRALDH1A1 | |
| SCHEMBL15086791 | 0.83 | PARP1 (0.52) | SMN1; SMN2PGRALDH1A1LMNAPKM | |
| SCHEMBL14484303 | 0.83 | MAOB (0.55) | SMN1; SMN2PGRALDH1A1LMNAPKM | |
| SCHEMBL14553603 | 0.83 | PGR (0.49) | SMN1; SMN2PGRALDH1A1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-12-28 | — | — | US | disclosed |
| US-20170368030-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-12-28 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-20140296238-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| EP-2726463-A2 | DIHYDROPYRAZOLES | Merck Patent GmbH (DE) | 2014-05-07 | — | — | EP | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| WO-2013006308-A2 | DIHYDROPYRAZOLES | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | WO | disclosed |
| WO-2013006308-A2 | DIHYDROPYRAZOLES | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | CYP3A4 459/4885USP2 4532/4885SMN1; SMN2 3843/4885 |
| US-20130172351-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | CYP3A4 459/4885USP2 4532/4885SMN1; SMN2 3843/4885 |
| US-20140296238-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | CYP3A4 459/4885USP2 4532/4885SMN1; SMN2 3843/4885 |
| US-20170071910-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | CYP3A4 459/4885USP2 4532/4885SMN1; SMN2 3843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.