Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.68 |
| ▸ | THRB | P10828 | 7/20 | 0.68 |
| ▸ | PPARG | P37231 | 3/20 | 0.68 |
| ▸ | RXRA | P19793 | 2/20 | 0.68 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.68 |
| ▸ | ITGAV | P06756 | 1/20 | 0.68 |
| ▸ | PCNA | P12004 | 9/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | PGR | P06401 | 1/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428790 | 0.88 | THRB (0.52) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL5742498 | 0.87 | PCNA (0.53) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL5742613 | 0.86 | PCNA (0.74) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL14485308 | 0.85 | PCNA (0.77) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL5742010 | 0.84 | PCNA (0.57) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL6859639 | 0.83 | PCNA (0.50) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL5859452 | 0.82 | THRB (0.62) | THRATHRBPPARGPTGS1AKR1C3 | |
| Tetrac SCHEMBL365951 | 0.81 | THRB (1.00) | THRATHRBPPARGRXRAITGB3 | |
| SCHEMBL6535223 | 0.81 | PCNA (0.49) | THRATHRBPPARGRXRAITGB3 | |
| Tiratricol SCHEMBL30161572 | 0.81 | THRB (1.00) | THRATHRBPPARGRXRAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140288077-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2014-09-25 | — | — | US | disclosed |
| US-20140288077-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2014-09-25 | — | — | US | disclosed |
| WO-2013006734-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288077-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | MKI67, PCNA, PCLAF | THRA 3069/4885THRB 2853/4885PPARG 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.