Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tiratricol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 11/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 9/20 | 1.00 |
| ▸ | PCNA | P12004 | 9/20 | 1.00 |
| ▸ | PPARG | P37231 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | RXRA | P19793 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 2/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 2/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tiratricol SCHEMBL25149 | 1.00 | THRB (1.00) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL743426 | 1.00 | THRB (1.00) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL8660328 | 0.99 | THRB (0.97) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL10701956 | 0.99 | THRB (0.97) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL2671904 | 0.99 | THRB (0.97) | THRBPCNATHRAPPARGLMNA | |
| SCHEMBL18573065 | 0.91 | THRB (0.82) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL5881667 | 0.90 | THRB (0.81) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL21624999 | 0.88 | THRB (0.77) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL9296273 | 0.88 | THRB (0.77) | THRBPCNATHRAPPARGLMNA | |
| SCHEMBL5858371 | 0.87 | THRB (0.78) | THRBPCNATHRAPPARGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115734784-A | Microneedle device for controlling thyroid hormone levels | 平衡治療有限責任公司 | 2023-03-03 | — | — | CN | claimed |
| WO-2026061910-A1 | CHEMICAL PROCESS AND COMPOSITIONS COMPRISING TIRATRICOL | RARE THYROID THERAPEUTICS INTERNATIONAL AB (SE) | 2026-03-26 | — | — | WO | disclosed |
| CN-117412772-A | Compositions and methods for dual targeted treatment of neuroendocrine tumors | 纳米药业有限责任公司 | 2024-01-16 | — | — | CN | disclosed |
| US-20230285342-A1 | COMPOSITIONS AND METHODS | Spectrix Therapeutics, LLC | 2023-09-14 | — | — | US | disclosed |
| CN-113181152-B | Application of Tiratricol compound in preparation of anti-EV 71 virus drugs | 湖北工业大学 | 2023-04-28 | — | — | CN | disclosed |