Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCNA | P12004 | 12/20 | 0.49 |
| ▸ | LIG1 | P18858 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 4/20 | 0.43 |
| ▸ | THRA | P10827 | 3/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005004 | 0.84 | PCNA (0.66) | PCNALIG1THRBTHRARXRA | |
| SCHEMBL7937662 | 0.83 | PCNA (0.47) | PCNALIG1THRBTHRARXRA | |
| SCHEMBL4428790 | 0.81 | THRB (0.52) | PCNATHRBTHRARXRAPPARG | |
| SCHEMBL14484752 | 0.81 | THRA (0.68) | PCNATHRBTHRARXRAPPARG | |
| SCHEMBL5014840 | 0.80 | PCNA (0.44) | PCNALIG1THRBTHRARXRA | |
| SCHEMBL5742498 | 0.80 | PCNA (0.53) | PCNATHRBTHRARXRAPPARG | |
| SCHEMBL4008223 | 0.79 | THRB (0.63) | THRBTHRARORC | |
| SCHEMBL28223321 | 0.79 | MAPT (0.50) | THRBTHRARXRAPPARGLMNA | |
| SCHEMBL14485308 | 0.79 | PCNA (0.77) | PCNATHRBTHRARXRAPPARG | |
| SCHEMBL7087278 | 0.78 | THRB (0.68) | PCNATHRBTHRARXRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003498-A4 | DI-ARYL ETHERS AND THEIR DERIVATIVES AS ANTI-CANCER AGENTS | BIOSOURCE TECH INC (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6169104-B1 | COMPOUNDS BIND TUBULIN AND EXHIBIT ANTI-MITOTIC PROPERTIES; USING SUCH COMPOUNDS TO INHIBIT ABNORMAL CELL MITOSIS AND, IN PARTICULAR, TO INHIBIT TUMOR CELL GROWTH | LARGE SCALE BIOLOGY CORPORATION | 2001-01-02 | — | — | US | disclosed |
| EP-1003498-A1 | DI-ARYL ETHERS AND THEIR DERIVATIVES AS ANTI-CANCER AGENTS | Biosource Technologies, Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998042328-A1 | DI-ARYL ETHERS AND THEIR DERIVATIVES AS ANTI-CANCER AGENTS | BIOSOURCE TECHNOLOGIES, INC. (US) | 1998-10-01 | — | — | WO | disclosed |