Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14486566 | 0.89 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDERCC1ERCC4 | |
| SCHEMBL14486894 | 0.86 | ALDH1A1 (0.39) | KDM4EALDH1A1HPGDERCC1ERCC4 | |
| SCHEMBL14486411 | 0.84 | ALDH1A1 (0.37) | KDM4EALDH1A1HPGDERCC1ERCC4 | |
| SCHEMBL1832226 | 0.83 | MAPK1 (0.38) | KDM4EALDH1A1HPGDERCC1ERCC4 | |
| SCHEMBL14486815 | 0.77 | ERCC1 (0.37) | KDM4EALDH1A1HPGDERCC1ERCC4 | |
| SCHEMBL14552900 | 0.77 | S1PR1 (0.47) | KDM4EALDH1A1HPGDS1PR1EGLN1 | |
| SCHEMBL1829171 | 0.76 | ALOX5 (0.36) | KDM4EALDH1A1HPGDERCC1ERCC4 | |
| SCHEMBL1829903 | 0.76 | DHPS (0.34) | KDM4EALDH1A1HPGDERCC1ERCC4 | |
| SCHEMBL14486747 | 0.76 | ERCC1 (0.36) | KDM4EALDH1A1HPGDERCC1ERCC4 | |
| SCHEMBL1829092 | 0.75 | S1PR1 (0.46) | KDM4EALDH1A1ALOX5MAPK1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321787-B2 | Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| US-9321787-B2 | Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| US-9321787-B2 | Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| EP-2729471-B1 | CARBOXYLIC ACID DERIVATIVES WITH AN OXAZOLO[5,4-D]PYRIMIDINE RING | SANOFI SA (FR) | 2015-05-06 | — | — | EP | disclosed |
| EP-2729471-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-D]PYRIDINE RING | SANOFI (FR) | 2014-05-14 | — | — | EP | disclosed |
| US-20130023544-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-d]PYRIMIDINE RING | SANOFI (FR) | 2013-01-24 | — | — | US | disclosed |
| US-20130023544-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-d]PYRIMIDINE RING | SANOFI (FR) | 2013-01-24 | — | — | US | disclosed |
| US-20130023544-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-d]PYRIMIDINE RING | SANOFI (FR) | 2013-01-24 | — | — | US | disclosed |
| WO-2013004827-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-D]PYRIDINE RING | SANOFI (FR) | 2013-01-10 | — | — | WO | disclosed |
| WO-2013004827-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-D]PYRIDINE RING | SANOFI (FR) | 2013-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023544-A1 | CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-d]PYRIMIDINE RING | OXGR1, CXCR1, DPYD | KDM4E 1559/4885ALDH1A1 33/4885HPGD 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.