Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14486417 | 0.91 | HTR1A (0.42) | DRD4HTR2AHTR1ADRD2SIGMAR1 | |
| SCHEMBL14486076 | 0.89 | SIGMAR1 (0.49) | DRD4HTR2AHTR1ADRD2SIGMAR1 | |
| SCHEMBL14486134 | 0.88 | SIGMAR1 (0.45) | DRD4HTR2AHTR1ADRD2SIGMAR1 | |
| SCHEMBL14488459 | 0.87 | PRKAA2 (0.35) | DRD4HTR2AHTR1ADRD2SIGMAR1 | |
| SCHEMBL14486750 | 0.86 | SMYD2 (0.42) | DRD4HTR2AHTR1ADRD2SIGMAR1 | |
| SCHEMBL14486933 | 0.84 | SIGMAR1 (0.43) | DRD4HTR2AHTR1ADRD2SIGMAR1 | |
| SCHEMBL14488276 | 0.82 | ABCC1 (0.45) | HTR1AHTR7 | |
| SCHEMBL14486516 | 0.82 | ABCC1 (0.43) | DRD4HTR2AHTR1ADRD2SIGMAR1 | |
| SCHEMBL14555554 | 0.81 | MAPT (0.40) | DRD4HTR1ADRD2SIGMAR1HTR7 | |
| SCHEMBL14488343 | 0.81 | MEN1 (0.36) | DRD4HTR2AHTR1ADRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | claimed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | claimed |