Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 3/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488343 | 0.96 | MEN1 (0.36) | DRD2DRD4HTR2AHTR1ASIGMAR1 | |
| SCHEMBL14488162 | 0.87 | DRD4 (0.44) | PRKAA2DRD2DRD4DRD3HTR2A | |
| SCHEMBL14488224 | 0.84 | KMT2A (0.46) | DRD2DRD4DRD3MEN1NPC1 | |
| SCHEMBL14486416 | 0.79 | KMT2A (0.48) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL14486248 | 0.79 | KMT2A (0.51) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL14486417 | 0.79 | HTR1A (0.42) | DRD2DRD4DRD3HTR2AHTR1A | |
| SCHEMBL14488129 | 0.79 | DRD2 (0.42) | DRD2DRD4DRD3HTR2AHTR1A | |
| SCHEMBL14488441 | 0.78 | KDM4E (0.43) | DRD2DRD3HTR2AHTR1ATMEM97 | |
| SCHEMBL14488125 | 0.78 | LMNA (0.52) | DRD2DRD4DRD3MEN1NPC1 | |
| SCHEMBL14488302 | 0.78 | CNR2 (0.39) | TMEM97SIGMAR1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | claimed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | claimed |