Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 8/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14486525 | 0.97 | FAAH (0.48) | FAAHSLC6A3SIGMAR1GRM2DRD2 | |
| SCHEMBL14486515 | 0.94 | FAAH (0.51) | FAAHSIGMAR1DRD2NPC1RAB9A | |
| SCHEMBL14488728 | 0.89 | FAAH (0.46) | FAAHSLC6A3SIGMAR1DRD2SLC6A4 | |
| SCHEMBL14486582 | 0.87 | FAAH (0.48) | FAAHSLC6A3SIGMAR1DRD2CNR2 | |
| SCHEMBL14488124 | 0.87 | FAAH (0.45) | FAAHSIGMAR1DRD2 | |
| SCHEMBL14488428 | 0.86 | FAAH (0.47) | FAAHSIGMAR1CNR2 | |
| SCHEMBL14488168 | 0.85 | FAAH (0.44) | FAAHSIGMAR1DRD2 | |
| SCHEMBL14488141 | 0.85 | FAAH (0.48) | FAAHSIGMAR1DRD2NPC1RAB9A | |
| SCHEMBL14488232 | 0.85 | FAAH (0.45) | FAAHSIGMAR1NPC1RAB9ACNR2 | |
| SCHEMBL14486079 | 0.85 | HTR1A (0.50) | FAAHSIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | claimed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | claimed |