Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14486342 | 0.95 | FAAH (0.48) | FAAHSIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL14486582 | 0.95 | FAAH (0.48) | FAAHSIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL14486415 | 0.92 | FAAH (0.51) | FAAHSIGMAR1HTR1AHTR7 | |
| SCHEMBL14486078 | 0.92 | FAAH (0.51) | FAAHHTR1ADRD2HTR2ADRD3 | |
| SCHEMBL14486079 | 0.87 | HTR1A (0.50) | FAAHSIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL14488192 | 0.87 | FAAH (0.46) | FAAHSIGMAR1DRD2 | |
| SCHEMBL14488568 | 0.87 | FAAH (0.48) | FAAHSIGMAR1HTR1AHTR7 | |
| SCHEMBL14488303 | 0.87 | HTR1A (0.46) | FAAHSIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL14486677 | 0.86 | SIGMAR1 (0.57) | FAAHSIGMAR1HTR1ADRD2DRD3 | |
| SCHEMBL14486842 | 0.86 | FAAH (0.56) | FAAHHTR1ADRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | claimed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | claimed |