Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488116 | 1.00 | FAAH (0.47) | FAAHSIGMAR1HTR1AABCB1DRD2 | |
| SCHEMBL14486551 | 0.91 | SIGMAR1 (0.55) | FAAHSIGMAR1HTR1AABCB1DRD2 | |
| SCHEMBL14486293 | 0.90 | SIGMAR1 (0.56) | FAAHSIGMAR1HTR1AABCB1ADRA1D | |
| SCHEMBL14486549 | 0.90 | FAAH (0.48) | FAAHSIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL14486590 | 0.89 | FAAH (0.50) | FAAHSIGMAR1DRD2DRD4 | |
| SCHEMBL14486576 | 0.88 | DRD2 (0.53) | FAAHSIGMAR1HTR1ADRD2DRD4 | |
| SCHEMBL14486342 | 0.88 | FAAH (0.48) | FAAHSIGMAR1HTR1ADRD2DRD4 | |
| SCHEMBL14486394 | 0.88 | SIGMAR1 (0.59) | FAAHSIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL14486630 | 0.87 | SIGMAR1 (0.56) | FAAHSIGMAR1HTR1ADRD2DRD4 | |
| SCHEMBL14486056 | 0.87 | SIGMAR1 (0.52) | FAAHSIGMAR1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | disclosed |