Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 9/20 | 0.64 |
| ▸ | PRKCB | P05771 | 8/20 | 0.64 |
| ▸ | PRKCH | P24723 | 5/20 | 0.64 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.64 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.57 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.50 |
| ▸ | PRKCG | P05129 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.50 |
| ▸ | PRKCI | P41743 | 2/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | PRKACG | P22612 | 3/20 | 0.49 |
| ▸ | PRKACB | P22694 | 3/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2954178 | 0.91 | PRKCA (0.69) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL14488754 | 0.84 | PRKCA (0.64) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL4675538 | 0.79 | PRKCA (1.00) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL2954182 | 0.78 | CAMK2D (0.65) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL2944710 | 0.78 | PRKCA (0.69) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL4681457 | 0.76 | PRKCA (0.74) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL4675940 | 0.75 | CAMK2D (0.56) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL4676697 | 0.75 | CAMK2D (0.67) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL13241407 | 0.74 | CCNT1 (0.70) | PRKCAPRKCBPRKCHPRKCQPRKCD | |
| SCHEMBL13241411 | 0.73 | CCNT1 (0.76) | PRKCACAMK2DPRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7232906-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BG) | 2007-06-19 | — | — | US | disclosed |
| US-7232906-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BG) | 2007-06-19 | — | — | US | disclosed |