Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 17/20 | 0.45 |
| ▸ | THRA | P10827 | 4/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488987 | 0.91 | THRB (0.52) | THRBTHRA | |
| SCHEMBL14488988 | 0.90 | THRB (0.53) | THRBTHRA | |
| SCHEMBL14489323 | 0.81 | THRB (0.39) | THRBTHRA | |
| SCHEMBL14488826 | 0.77 | THRB (0.51) | THRBTHRA | |
| SCHEMBL7042656 | 0.77 | THRB (0.49) | THRBTHRACHRM4 | |
| SCHEMBL14489016 | 0.76 | THRB (0.51) | THRBTHRA | |
| SCHEMBL14488858 | 0.75 | THRB (0.53) | THRBTHRA | |
| SCHEMBL14488845 | 0.74 | THRB (0.46) | THRBTHRA | |
| SCHEMBL1640963 | 0.74 | THRB (0.80) | THRBTHRA | |
| SCHEMBL14488977 | 0.71 | THRB (0.53) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230031-B2 | Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-06-12 | — | — | US | disclosed |