Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.39 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12305071 | 0.84 | MAPT (0.59) | FYNDRD2DRD1MAPTHIF1A | |
| SCHEMBL630831 | 0.84 | HTR2A (0.46) | FYNDRD2DRD1MAPTHIF1A | |
| SCHEMBL13799411 | 0.75 | DRD2 (0.50) | DRD2DRD1MAPTHIF1AHSD17B10 | |
| SCHEMBL3659349 | 0.74 | MAPT (0.33) | MAPTALDH1A1TSHR | |
| SCHEMBL19449349 | 0.73 | FYN (0.36) | FYNDRD2DRD1MAPTHIF1A | |
| SCHEMBL16233626 | 0.72 | HTR2C (0.41) | ALDH1A1 | |
| SCHEMBL14259452 | 0.72 | HTR2A (0.32) | — | |
| SCHEMBL21205773 | 0.72 | DRD2 (0.32) | FYNDRD2DRD1 | |
| SCHEMBL22039120 | 0.72 | FYN (0.44) | FYNDRD2DRD1MAPTHIF1A | |
| SCHEMBL1878747 | 0.69 | LMNA (0.42) | FYNDRD2DRD1MAPTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007073503-A2 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-28 | — | — | WO | disclosed |