SCHEMBL14489792

SCHEMBL14489792

O=C(CCC(=O)N1CCc2ccccc2C1)c1ccc2c(c1)CCNCC2

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 5/20 0.59
ACHE P22303 1/20 0.52
HDAC3 O15379 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC10 Q969S8 1/20 0.51
HDAC11 Q96DB2 1/20 0.51
HPGD P15428 4/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
TSHR P16473 1/20 0.49
HSD17B10 Q99714 1/20 0.49
GAA P10253 1/20 0.48
CTNNB1 P35222 1/20 0.48
WNT3A P56704 1/20 0.48
ALDH1A1 P00352 4/20 0.47
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5419451 0.93 MCHR1 (0.52) MCHR1ACHEHDAC3HDAC1HDAC10
SCHEMBL14489791 0.83 MCHR1 (0.66) MCHR1ACHESMN1; SMN2CTNNB1WNT3A
SCHEMBL14489855 0.82 MCHR1 (0.59) MCHR1ACHESMN1; SMN2GAACTNNB1
SCHEMBL19931583 0.81 HPGD (0.63) HDAC3HDAC1HDAC10HDAC11HPGD
SCHEMBL14489799 0.81 MCHR1 (0.64) MCHR1ACHEHPGDSMN1; SMN2HSD17B10
SCHEMBL14489796 0.81 MCHR1 (0.64) MCHR1ACHESMN1; SMN2CTNNB1WNT3A
SCHEMBL14489748 0.80 MCHR1 (0.81) MCHR1ACHECTNNB1WNT3A
SCHEMBL14489854 0.80 ACHE (0.70) MCHR1ACHEHPGDSMN1; SMN2TSHR
SCHEMBL14489806 0.80 MCHR1 (0.72) MCHR1ACHESMN1; SMN2CTNNB1WNT3A
SCHEMBL14489856 0.79 MCHR1 (0.56) MCHR1ACHEALDH1A1NPC1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7229986-B2 Melanin-concentrating hormone antagonist TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) 2007-06-12 US disclosed
US-7229986-B2 Melanin-concentrating hormone antagonist TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) 2007-06-12 US disclosed