Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 11/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | MYLK | Q15746 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | THPO | P40225 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128136 | 0.87 | CYP3A4 (0.58) | TRPV4CCR1GAACYP3A4CYP1A2 | |
| SCHEMBL4140000 | 0.79 | CCR1 (0.47) | TRPV4CCR1GAACNR1CNR2 | |
| SCHEMBL1148963 | 0.78 | TRPV4 (0.51) | TRPV4CCR1GAA | |
| SCHEMBL4771481 | 0.78 | L3MBTL1 (0.64) | TRPV4CCR1GAACYP3A4CYP1A2 | |
| SCHEMBL26921542 | 0.77 | CCR2 (0.52) | GAACYP3A4CSNK1A1CYP1A2CYP2D6 | |
| SCHEMBL4767555 | 0.75 | POLB (0.63) | TRPV4GAAKDM4E | |
| SCHEMBL15127571 | 0.74 | GAA (0.51) | TRPV4CCR1GAAKDM4E | |
| SCHEMBL9577232 | 0.74 | GAA (0.69) | CCR1GAAHSD17B10MAPK1 | |
| SCHEMBL14360846 | 0.73 | CCR1 (0.52) | TRPV4CCR1GAACYP3A4CSNK1A1 | |
| SCHEMBL418863 | 0.73 | MAPT (0.50) | TRPV4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070865-A2 | PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |