Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HK1 | P19367 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3456787 | 0.89 | PTGDR2 (0.36) | SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL14498578 | 0.84 | KMT2A (0.40) | ALDH1A1HK1SMN1; SMN2HKDC1HTT | |
| SCHEMBL14498575 | 0.83 | TSHR (0.41) | ALDH1A1HK1SMN1; SMN2HKDC1KMT2A | |
| SCHEMBL6220473 | 0.81 | KMT2A (0.50) | ALDH1A1KMT2ATSHRTP53MAPT | |
| SCHEMBL7213388 | 0.81 | TSHR (0.41) | ALDH1A1KMT2ATSHRTP53MAPT | |
| SCHEMBL14498577 | 0.81 | KMT2A (0.43) | ALDH1A1HTTKMT2ATSHRMAPT | |
| SCHEMBL14498582 | 0.80 | TSHR (0.41) | ALDH1A1KMT2ATSHRCYP1A2CYP2C9 | |
| SCHEMBL14498590 | 0.79 | TSHR (0.40) | ALDH1A1KMT2ATSHRCYP1A2CYP2C9 | |
| SCHEMBL14498579 | 0.79 | RAB9A (0.44) | ALDH1A1HK1SMN1; SMN2HKDC1HTT | |
| SCHEMBL6220470 | 0.79 | ALDH1A1 (0.42) | ALDH1A1HTTKMT2ATSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |