Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3462977 | 0.88 | CXCR2 (0.36) | CYP2C9 | |
| SCHEMBL14498575 | 0.85 | TSHR (0.41) | TSHRRAB9AKMT2AMEN1TDP1 | |
| SCHEMBL6220473 | 0.85 | KMT2A (0.50) | TSHRRAB9AKMT2AMEN1TDP1 | |
| SCHEMBL14498582 | 0.84 | TSHR (0.41) | TSHRRAB9AKMT2AMEN1TDP1 | |
| SCHEMBL14498590 | 0.84 | TSHR (0.40) | TSHRRAB9AKMT2AMEN1TDP1 | |
| SCHEMBL14498541 | 0.83 | TSHR (0.41) | TSHRRAB9AKMT2AMEN1TDP1 | |
| SCHEMBL14498591 | 0.82 | TSHR (0.39) | TSHRRAB9AKMT2AMEN1TDP1 | |
| SCHEMBL14498577 | 0.81 | KMT2A (0.43) | TSHRRAB9AKMT2AMEN1TDP1 | |
| SCHEMBL14498579 | 0.81 | RAB9A (0.44) | TSHRRAB9AKMT2AMEN1TDP1 | |
| SCHEMBL14498581 | 0.81 | ALDH1A1 (0.41) | TSHRRAB9AKMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326841-A1 | PYRIDINONE DERIVATIVES FOR TREATMENT OF ATHEROSCLEROSIS | SmithKline Beecham P.L.C. (GB) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030904-A1 | PYRIDINONE DERIVATIVES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-18 | — | — | WO | disclosed |