SCHEMBL14499355

SCHEMBL14499355

Cc1ccc(N2CCC(CCOc3ccc4nn(C)nc4c3)CC2)nn1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.39
PPARD Q03181 3/20 0.39
OGA O60502 1/20 0.38
GPR119 Q8TDV5 2/20 0.36
NR1I2 O75469 1/20 0.36
PPARA Q07869 2/20 0.35
PDE2A O00408 1/20 0.35
CTSS P25774 2/20 0.34
CHEK2 O96017 2/20 0.33
ACACB O00763 1/20 0.33
MAOA P21397 1/20 0.33
HPGD P15428 1/20 0.33
ENPP1 P22413 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12619638 0.91 PPARG (0.37) PPARGPPARDOGAGPR119NR1I2
SCHEMBL12269515 0.86 PPARG (0.36) PPARGPPARDOGAGPR119NR1I2
SCHEMBL13021436 0.84 PPARG (0.43) PPARGPPARDOGAGPR119NR1I2
SCHEMBL13021438 0.82 PPARG (0.39) PPARGPPARDOGAGPR119NR1I2
SCHEMBL1665706 0.82 PPARG (0.42) PPARGPPARDOGAGPR119NR1I2
SCHEMBL9986408 0.81 GPR119 (0.45) GPR119NR1I2
SCHEMBL10327520 0.81 NR1I2 (0.43) PPARGPPARDOGAGPR119NR1I2
SCHEMBL14491320 0.81 NR1I2 (0.43) PPARGPPARDOGAGPR119NR1I2
SCHEMBL1664257 0.80 PPARG (0.37) PPARGPPARDOGAGPR119NR1I2
SCHEMBL12796417 0.80 PPARG (0.37) PPARGPPARDOGAGPR119NR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070149530-A1 For treatment of picornavirus infections in mammals BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 2007-06-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149530-A1 For treatment of picornavirus infections in mammals HAVCR2, EIF2AK2, MAVS PPARG 1962/4885PPARD 2564/4885OGA 4758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.