Sugi Predict

Sugi Predict / Compounds / SCHEMBL1449948

SCHEMBL1449948

SCHEMBL1449948

O=C(Cc1ccoc1)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.49
▸ L3MBTL1 Q9Y468 3/20 0.49
▸ SRD5A2 P31213 2/20 0.47
▸ TDP1 Q9NUW8 3/20 0.47
▸ KDM4E B2RXH2 3/20 0.47
▸ MAPK1 P28482 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ CES1 P23141 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ PLAU P00749 1/20 0.45
▸ GSK3B P49841 2/20 0.44
▸ ALDH1A1 P00352 2/20 0.44
▸ PTPN1 P18031 2/20 0.44
▸ TRPA1 O75762 1/20 0.44
▸ HIF1A Q16665 1/20 0.44
▸ GPR52 Q9Y2T5 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5337050 0.85 TRPA1 (0.51) MAPTL3MBTL1SRD5A2CYP3A4PTPN1
SCHEMBL1515702 0.81 GPR52 (0.54) MAPTL3MBTL1SRD5A2KDM4ESMN1; SMN2
SCHEMBL4282905 0.80 MAPT (0.70) MAPTL3MBTL1SRD5A2TDP1KDM4E
SCHEMBL24800 0.78 MAPT (0.73) MAPTL3MBTL1SRD5A2TDP1KDM4E
SCHEMBL7199268 0.78 MAPT (0.67) MAPTL3MBTL1SRD5A2TDP1KDM4E
Water SCHEMBL9243001 0.76 MAPT (0.70) MAPTL3MBTL1SRD5A2TDP1KDM4E
Water SCHEMBL20527670 0.76 MAPT (0.70) MAPTL3MBTL1SRD5A2TDP1KDM4E
Bicarbonate SCHEMBL28984888 0.76 MAPT (0.70) MAPTL3MBTL1SRD5A2TDP1KDM4E
Hydrochloric Acid SCHEMBL27315608 0.76 MAPT (0.70) MAPTL3MBTL1SRD5A2TDP1KDM4E
SCHEMBL15988635 0.76 TRPA1 (0.59) MAPTL3MBTL1TDP1KDM4EMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1794157-B1 2-ACYLAMINOTHIAZOLE DERIVATIVES LUNDBECK & CO AS H (DK) 2014-02-26 — — EP disclosed
EP-1794157-B1 2-ACYLAMINOTHIAZOLE DERIVATIVES LUNDBECK & CO AS H (DK) 2014-02-26 — — EP disclosed
US-7910613-B2 2-acylaminothiazole derivatives H. LUNDBECK A/S (DK) 2011-03-22 — — US disclosed
US-7910613-B2 2-acylaminothiazole derivatives H. LUNDBECK A/S (DK) 2011-03-22 — — US disclosed
US-7910613-B2 2-acylaminothiazole derivatives H. LUNDBECK A/S (DK) 2011-03-22 — — US disclosed
US-20090137642-A1 2-Acylaminothiazole Derivatives H. LUNDBECK A/S (DK) 2009-05-28 — — US disclosed
US-20090137642-A1 2-Acylaminothiazole Derivatives H. LUNDBECK A/S (DK) 2009-05-28 — — US disclosed
US-20090137642-A1 2-Acylaminothiazole Derivatives H. LUNDBECK A/S (DK) 2009-05-28 — — US disclosed
EP-1794157-A1 2-ACYLAMINOTHIAZOLE DERIVATIVES H.Lundbeck A/S (DK) 2007-06-13 — — EP disclosed
WO-2006032273-A1 2-ACYLAMINOTHIAZOLE DERIVATIVES H. LUNDBECK A/S (DK) 2006-03-30 — — WO disclosed
WO-2006032273-A1 2-ACYLAMINOTHIAZOLE DERIVATIVES H. LUNDBECK A/S (DK) 2006-03-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137642-A1 2-Acylaminothiazole Derivatives ADORA2A, HTR2C, ADORA2B MAPT 487/4885L3MBTL1 3210/4885SRD5A2 1138/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.