SCHEMBL14499583

SCHEMBL14499583

CC(C)c1nc2cc(-c3c4ccccc4c(-c4ccc(-c5cccc6ccccc56)cc4)c4ccccc34)ccc2n1-c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 4/20 0.40
CYP1A2 P05177 3/20 0.40
PPARG P37231 5/20 0.38
PPARA Q07869 5/20 0.38
CRBN Q96SW2 1/20 0.38
CNR2 P34972 1/20 0.36
ALDH1A1 P00352 1/20 0.36
NTSR1 P30989 1/20 0.35
ENPP3 O14638 1/20 0.35
ENPP1 P22413 1/20 0.35
CYP2C9 P11712 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
MAPT P10636 1/20 0.34
CYP2C19 P33261 1/20 0.34
PTGER4 P35408 1/20 0.34
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2604844 0.89 CNR2 (0.45) PDE10ACYP1A2PPARGPPARACRBN
SCHEMBL14499584 0.87 PDE10A (0.47) PDE10ACYP1A2CRBNALDH1A1CYP2C9
SCHEMBL14499577 0.85 ALDH1A1 (0.52) PDE10AALDH1A1ENPP3ENPP1SMN1; SMN2
SCHEMBL2604826 0.84 CNR2 (0.45) PDE10ACYP1A2CRBNCNR2
SCHEMBL24813337 0.83 PDE10A (0.38) PDE10ACYP1A2CRBN
SCHEMBL14499591 0.83 PDE10A (0.44) PDE10ACYP1A2CRBNALDH1A1CYP2C9
SCHEMBL14363367 0.81 SIRT2 (0.41) ALDH1A1ENPP3ENPP1MAPTPTGER4
SCHEMBL2604827 0.80 CRBN (0.43) PDE10ACYP1A2CRBNCNR2NPSR1
SCHEMBL14499572 0.79 ALDH1A1 (0.53) PDE10AALDH1A1SMN1; SMN2PTGER4HSD17B10
SCHEMBL2604825 0.79 CRBN (0.47) PDE10ACYP1A2CRBNCNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070138950-A1 NITROGENOUS HETEROCYCLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-06-21 US disclosed
US-20070138950-A1 NITROGENOUS HETEROCYCLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070138950-A1 NITROGENOUS HETEROCYCLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME EHD1, HCN2, ODC1 PDE10A 1885/4885CYP1A2 1906/4885PPARG 4119/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.