Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 13/20 | 0.57 |
| ▸ | DRD2 | P14416 | 12/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5414076 | 1.00 | DRD4 (0.57) | DRD4DRD2HTR1AHTR2ASLC6A2 | |
| SCHEMBL14532757 | 1.00 | DRD4 (0.57) | DRD4DRD2HTR1AHTR2ASLC6A2 | |
| SCHEMBL14532761 | 0.81 | DRD2 (0.66) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL5406963 | 0.81 | DRD2 (0.66) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL14533031 | 0.76 | DRD4 (0.58) | DRD4DRD2HTR1AHTR2AL3MBTL1 | |
| SCHEMBL5410741 | 0.76 | DRD4 (0.58) | DRD4DRD2HTR1AHTR2AL3MBTL1 | |
| SCHEMBL14502920 | 0.76 | DRD4 (0.58) | DRD4DRD2HTR1AHTR2AL3MBTL1 | |
| SCHEMBL14502919 | 0.75 | DRD4 (0.48) | DRD4DRD2HTR1AHTR2ASLC6A2 | |
| SCHEMBL14532759 | 0.75 | DRD4 (0.48) | DRD4DRD2HTR1AHTR2ASLC6A2 | |
| SCHEMBL8642030 | 0.74 | HTR2A (0.45) | DRD4DRD2HTR2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220753-B2 | 2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives as ligands for serotonin receptors | PFIZER INC. (US) | 2007-05-22 | — | — | US | disclosed |