Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641073 | 0.81 | HTR2A (0.58) | HTR2AHTR2CHTR7CYP2D6HTR6 | |
| SCHEMBL467404 | 0.75 | KDM2B (0.53) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL8646880 | 0.75 | KDM2B (0.53) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL467405 | 0.75 | KDM2B (0.53) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL467403 | 0.75 | KDM2B (0.53) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL14532757 | 0.74 | DRD4 (0.57) | HTR2ASLC6A2DRD2DRD4 | |
| SCHEMBL14502917 | 0.74 | DRD4 (0.57) | HTR2ASLC6A2DRD2DRD4 | |
| SCHEMBL5414076 | 0.74 | DRD4 (0.57) | HTR2ASLC6A2DRD2DRD4 | |
| SCHEMBL8642032 | 0.70 | KDM4E (0.55) | — | |
| SCHEMBL1348883 | 0.69 | HTR2A (0.58) | HTR2AHTR2CHTR7CYP2D6HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731307-A | Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines | PFIZER, INC. (US) | 1998-03-24 | — | — | US | claimed |