Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 12/20 | 0.58 |
| ▸ | DRD2 | P14416 | 11/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14502920 | 1.00 | DRD4 (0.58) | DRD4DRD2L3MBTL1KDM4EMEN1 | |
| SCHEMBL14533031 | 1.00 | DRD4 (0.58) | DRD4DRD2L3MBTL1KDM4EMEN1 | |
| SCHEMBL5420474 | 0.82 | DRD4 (0.66) | DRD4DRD2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL14502925 | 0.82 | DRD4 (0.66) | DRD4DRD2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5420478 | 0.82 | DRD4 (0.66) | DRD4DRD2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL14532764 | 0.82 | DRD4 (0.66) | DRD4DRD2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6212106 | 0.80 | L3MBTL1 (0.62) | DRD4DRD2L3MBTL1KDM4EMEN1 | |
| SCHEMBL5414076 | 0.76 | DRD4 (0.57) | DRD4DRD2L3MBTL1HTR1AHTR2A | |
| SCHEMBL14502917 | 0.76 | DRD4 (0.57) | DRD4DRD2L3MBTL1HTR1AHTR2A | |
| SCHEMBL14532757 | 0.76 | DRD4 (0.57) | DRD4DRD2L3MBTL1HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220753-B2 | 2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives as ligands for serotonin receptors | PFIZER INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20040214830-A1 | 2,7-Substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives as ligands for serotonin receptors | DESAI KISHOR A | 2004-10-28 | — | — | US | disclosed |
| US-20030055061-A1 | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors | PFIZER INC. | 2003-03-20 | — | — | US | disclosed |
| US-20020132811-A1 | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors | DESAI KISHOR A (US) | 2002-09-19 | — | — | US | disclosed |
| EP-0783503-B1 | 2,7-SUBSTITUTED OCTAHYDRO-1H-PYRIDO[ 1,2-A]PYRAZINE DERIVATIVES | PFIZER (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6231833-B1 | ADMINISTERING TO THE MAMMAL FOR TREATING SEROTONIN SYSTEM RELATED DISORDERS AN EFFECTIVE AMOUNT OF 2,7-SUBSTITUTED OCTAHYDRO-1H-PYRIDO(1,2-A)PYRAZINE DERIVATIVE AS LIGANDS FOR SEROTONIN RECEPTOR | PFIZER INC | 2001-05-15 | — | — | US | disclosed |
| EP-1074257-A1 | 2,7-Substituted octahydro-1H-pyrido (1,2-A)pyrazine derivatives as ligands for serotonin receptors | Pfizer Products Inc. (US) | 2001-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020132811-A1 | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors | HTR2C, HTR1A, HTR3A | DRD4 65/4885DRD2 27/4885L3MBTL1 4277/4885 |
| US-20040214830-A1 | 2,7-Substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives as ligands for serotonin receptors | HTR2C, HTR1A, HTR3A | DRD4 65/4885DRD2 27/4885L3MBTL1 4277/4885 |
| US-20030055061-A1 | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors | HTR2C, HTR1A, HTR3A | DRD4 65/4885DRD2 27/4885L3MBTL1 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.