Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223960 | 0.85 | HPGD (0.70) | ALDH1A1HPGDMAPK1MEN1KMT2A | |
| SCHEMBL4392112 | 0.84 | POLB (0.65) | ALDH1A1HPGDPOLBMEN1KMT2A | |
| SCHEMBL6617073 | 0.84 | HPGD (0.74) | ALDH1A1HPGDMAPK1MEN1KMT2A | |
| SCHEMBL20179971 | 0.82 | KMT2A (0.49) | ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL28142722 | 0.82 | HPGD (0.50) | ALDH1A1HPGDPOLBMAPK1GPR183 | |
| SCHEMBL1662915 | 0.81 | PHGDH (0.65) | ALDH1A1HPGDPOLBMAPK1KMT2A | |
| SCHEMBL15172602 | 0.81 | SIGMAR1 (0.64) | ALDH1A1HPGDGPR183 | |
| SCHEMBL25167884 | 0.80 | L3MBTL3 (0.47) | ALDH1A1HPGDPOLBGPR183MEN1 | |
| SCHEMBL522002 | 0.80 | CHRNA7 (0.61) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2044543 | 0.80 | KMT2A (0.58) | ALDH1A1HPGDPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015069110-A1 | MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS | AAPA B.V. (NL) | 2015-05-14 | — | — | WO | disclosed |
| US-7910582-B2 | Cyclopropyl amines as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-22 | — | — | US | disclosed |