Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 5/20 | 1.00 |
| ▸ | KCNQ2 | O43526 | 5/20 | 1.00 |
| ▸ | KCNQ5 | Q9NR82 | 4/20 | 1.00 |
| ▸ | KCNE1 | P15382 | 3/20 | 1.00 |
| ▸ | KCNQ1 | P51787 | 3/20 | 1.00 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.63 |
| ▸ | JUN | P05412 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.63 |
| ▸ | RELA | Q04206 | 1/20 | 0.63 |
| ▸ | BTK | Q06187 | 3/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213061 | 0.87 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516640 | 0.84 | KCNQ3 (0.74) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL4722613 | 0.84 | KCNQ3 (0.73) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL24274710 | 0.84 | KCNQ3 (0.72) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5131380 | 0.82 | RHOC (0.80) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5346150 | 0.82 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL39874 | 0.82 | KCNQ3 (0.70) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5345894 | 0.81 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL4286068 | 0.81 | MAPT (0.94) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL2494570 | 0.81 | CSF1R (0.81) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| EP-1483259-A4 | PYRIMIDINES AS NOVEL OPENERS OF POTASSIUM ION CHANNELS | ICAGEN INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1483259-A1 | PYRIMIDINES AS NOVEL OPENERS OF POTASSIUM ION CHANNELS | Icagen, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20030181465-A1 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. | 2003-09-25 | — | — | US | disclosed |
| WO-2003068767-A1 | PYRIMIDINES AS NOVEL OPENERS OF POTASSIUM ION CHANNELS | ICAGEN, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181465-A1 | Pyrimidines as novel openers of potassium ion channels | KCNJ1, KCNJ2, KCNJ11 | KCNQ3 22/4885KCNQ2 12/4885KCNQ5 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.