Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 14/20 | 0.82 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778231 | 0.90 | ADORA2B (1.00) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL14267752 | 0.89 | ADORA2B (0.64) | ADORA2BADORA1ADORA2A | |
| SCHEMBL5334257 | 0.85 | ADORA2B (0.82) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL5336024 | 0.84 | ADORA2B (0.83) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1780628 | 0.80 | ADORA2B (1.00) | ADORA2BADORA1ADORA2A | |
| SCHEMBL4759172 | 0.80 | ADORA2B (0.73) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1780657 | 0.80 | ADORA2B (1.00) | ADORA2BADORA1ADORA2A | |
| SCHEMBL1569329 | 0.78 | ADORA2B (0.89) | ADORA2BADORA1ADORA2A | |
| SCHEMBL1779738 | 0.76 | ADORA2B (1.00) | ADORA2BADORA1ADORA2A | |
| SCHEMBL1779460 | 0.74 | ADORA2B (0.81) | ADORA2BADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205403-B2 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205403-B2 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2007-04-17 | — | — | US | disclosed |